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Serum 25(OH)D levels do not indicate the amount of vitamin D stored in body tissues. 25(OH)D functions as a biomarker of exposure, but it is not clear to what extent 25(OH)D levels also serve as a biomarker of effect (i.e., relating to health status or outcomes). It reflects vitamin D produced cutaneously and that obtained from food and supplements and has a fairly long circulating half-life of 15 days. Serum concentration of 25(OH)D is the best indicator of vitamin D status. Many cells have vitamin D receptors, and some convert 25(OH)D to 1,25(OH) 2D. Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by vitamin D. Vitamin D has other roles in the body, including modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. Together with calcium, vitamin D also helps protect older adults from osteoporosis. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults. Without sufficient vitamin D, bones can become thin, brittle, or misshapen. It is also needed for bone growth and bone remodeling by osteoblasts and osteoclasts. Vitamin D promotes absorption in the gut and maintains adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and to prevent hypocalcemic tetany. The second occurs primarily in the kidney and forms the physiologically active 1,25-dihydroxyvitamin D, also known as calcitriol.
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Super Dvr Software For Windows 7 Download. The first occurs in the liver and converts vitamin D to 25-hydroxyvitamin D, also known as calcidiol. Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation.
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It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis.
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Archived from the original on 20 April 2016.
